Technology Process of 6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-amine
There total 7 articles about 6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmcl.2020.127456
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / methanol / 35 °C / 22801.5 Torr / Autoclave; Large scale
2.1: formic acid / water / 16 h / Inert atmosphere
2.2: 0.5 h / 15 - 25 °C
3.1: methanol / 0.25 h / 0 °C
3.2: 3 h / 0 °C
4.1: trifluoroacetic acid; nitric acid / 1 h
5.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 40 °C
With
methanol; formic acid; palladium on activated charcoal; hydrogen; nitric acid; trifluoroacetic acid;
In
methanol; water;
DOI:10.1021/acsmedchemlett.1c00096
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: formic acid / water / 16 h / Inert atmosphere
1.2: 0.5 h / 15 - 25 °C
2.1: methanol / 0.25 h / 0 °C
2.2: 3 h / 0 °C
3.1: trifluoroacetic acid; nitric acid / 1 h
4.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 40 °C
With
methanol; formic acid; palladium on activated charcoal; hydrogen; nitric acid; trifluoroacetic acid;
In
methanol; water;
DOI:10.1021/acsmedchemlett.1c00096
