N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide

Base Information

• Chemical Name: N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide
• CAS No.: 1400815-07-7
• Molecular Formula: C₁₃H₁₀N₂O₃S
• Molecular Weight: 274.3
• Mol file: 1400815-07-7.mol

Synonyms:

Chemical Property of N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide

There total 3 articles about N'-(1,3-benzodioxol-5-ylmethylene)-2-thiophenecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-thienylhydrazide (2361-27-5) + piperonal (120-57-0,30024-74-9) → (E)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)thiophene-2-carbohydrazide (1400815-07-7)

Guidance literature:

2-thienylhydrazide; piperonal; With hydrogenchloride; In ethanol; water; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water;

DOI:10.1016/j.ejmech.2012.06.056

Reference yield:

thiophene-2-carboxylic acid methyl ester (5380-42-7) → (E)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)thiophene-2-carbohydrazide (1400815-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3.5 h / 70 °C

2: hydrogenchloride / ethanol; water / 1 h / 20 °C

With hydrogenchloride; hydrazine hydrate; In ethanol; water;

DOI:10.1016/j.ejmech.2012.06.056

Reference yield:

thiophene-2-carbaldehyde (98-03-3) → (E)-N'-(benzo[d][1,3]dioxol-5-ylmethylene)thiophene-2-carbohydrazide (1400815-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogen sulfate; iodine; potassium hydroxide / 2 h / 0 °C

2: hydrazine hydrate / ethanol / 3.5 h / 70 °C

3: hydrogenchloride / ethanol; water / 1 h / 20 °C

With hydrogenchloride; sodium hydrogen sulfate; iodine; hydrazine hydrate; potassium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2012.06.056

upstream raw materials:

2-thienylhydrazide

piperonal

thiophene-2-carboxylic acid methyl ester

thiophene-2-carbaldehyde

Refernces