1,1,1-trifluoro-2-(2-nitrophenyl)ethane

Base Information

• Chemical Name: 1,1,1-trifluoro-2-(2-nitrophenyl)ethane
• CAS No.: 145914-06-3
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.136
• Hs Code.: 2904990090
• Mol file: 145914-06-3.mol

Synonyms:

Chemical Property of 1,1,1-trifluoro-2-(2-nitrophenyl)ethane

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-Nitro-2-(2,2,2-trifluoroethyl)benzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1-trifluoro-2-(2-nitrophenyl)ethane

There total 6 articles about 1,1,1-trifluoro-2-(2-nitrophenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt (147531-11-1) + 2-nitrophenylmethyl bromide (3958-60-9) → 1,1,1-trifluoro-2-(2-nitrophenyl)ethane (145914-06-3)

Guidance literature:

With copper; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 11h; Inert atmosphere;

DOI:10.1021/ol201205t

Reference yield: 72.0%

Togni's reagent II (887144-94-7) + 2-nitro-benzaldehyde hydrazone (3718-21-6) → 1,1,1-trifluoro-2-(2-nitrophenyl)ethane (145914-06-3)

Guidance literature:

In dimethyl sulfoxide; at 80 ℃; for 24h; Temperature; Solvent; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.9b02072

Reference yield: 42.0%

2-(2-nitrophenyl)acetic acid (3740-52-1) → 1,1,1-trifluoro-2-(2-nitrophenyl)ethane (145914-06-3)

Guidance literature:

With sulfur tetrafluoride; at 20 ℃; for 72h; Autoclave;

DOI:10.1055/s-0031-1290295

upstream raw materials:

dibromodifluoromethane

2-Nitrobenzyl alcohol

trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt

2-nitrophenylmethyl bromide

Refernces

• 1、 Zhao, Zhensheng,Ma, Kevin C. Y.,Legault, Claude Y.,Murphy, Graham K.. "Denitrogenative Hydrotrifluoromethylation of Benzaldehyde Hydrazones: Synthesis of (2,2,2-Trifluoroethyl)arenes". supporting information. p. 11240 - 11245. Retrieved 2019/08/20.
• 2、 Kawai, Hiroyuki,Furukawa, Tatsuya,Nomura, Yoshinori,Tokunaga, Etsuko,Shibata, Norio. "Cu-mediated chemoselective trifluoromethylation of benzyl bromides using shelf-stable electrophilic trifluoromethylating reagents". supporting information; experimental part. p. 3596 - 3599. Retrieved 2011/09/16.