methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

Base Information

Chemical Name:methyl 2-(2-amino-6-bromopyridin-4-yl)acetate
CAS No.:89980-80-3
Molecular Formula:C₈H₉BrN₂O₂
Molecular Weight:245.076
Hs Code.:

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Chemical Property of methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

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Technology Process of methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

There total 6 articles about methyl 2-(2-amino-6-bromopyridin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.7%

: methyl 2-(2-bromo-6-(tert-butylamino)pyridin-4-yl)acetate

: 89980-80-3
methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

Guidance literature:: With trifluoroacetic acid; at 70 ℃; for 2h; Inert atmosphere;

Reference yield:

: 180608-37-1
2-bromo-6-fluoro-4-methylpyridine

: 89980-80-3
methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chromium(VI) oxide; sulfuric acid / 16 h / 20 - 50 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 °C

2.2: 3 h / 0 °C

2.3: 12 h / 100 °C

3.1: sulfuric acid / 0 - 60 °C

4.1: 1-methyl-pyrrolidin-2-one / 24 h / 100 °C / Sealed tube

5.1: trifluoroacetic acid / 2 h / 70 °C / Inert atmosphere

With chromium(VI) oxide; oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 2-bromo-6-fluoroisonicotinic acid

: 89980-80-3
methyl 2-(2-amino-6-bromopyridin-4-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 °C

1.2: 3 h / 0 °C

1.3: 12 h / 100 °C

2.1: sulfuric acid / 0 - 60 °C

3.1: 1-methyl-pyrrolidin-2-one / 24 h / 100 °C / Sealed tube

4.1: trifluoroacetic acid / 2 h / 70 °C / Inert atmosphere

With oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;