2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride

Base Information

• Chemical Name: 2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride
• CAS No.: 736173-15-2
• Molecular Formula: C₁₇H₁₄BrNO*ClH
• Molecular Weight: 364.669
• DSSTox Substance ID: DTXSID00588737
• Mol file: 736173-15-2.mol

Synonyms:736173-15-2;2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride;DTXSID00588737;MFCD07366599;AKOS025295668;AB30985;2-(Amino(3-bromophenyl)methyl)naphthalen-1-ol hydrochloride;2-[amino-(3-bromophenyl)methyl]naphthalen-1-ol;hydrochloride;2-[Amino(3-bromophenyl)methyl]naphthalen-1-ol--hydrogen chloride (1/1)

Chemical Property of 2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride

Chemical Property:

• Vapor Pressure: 1.87E-11mmHg at 25°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 363.00255
• Heavy Atom Count: 21
• Complexity: 324

Purity/Quality:

98%Min ^*data from raw suppliers

2-(AMINO-(3-BROMO-PHENYL)-METHYL)-NAPHTHALEN-1-OL HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2O)C(C3=CC(=CC=C3)Br)N.Cl

Technology Process of 2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride

There total 2 articles about 2-[Amino-(3-bromo-phenyl)-methyl]-naphthalen-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-naphthol (90-15-3) → 2-(α-amino-3-bromobenzyl)-1-naphthol hydrochloride (736173-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / methanol / 48 h / 20 °C

2: 9.48 g / 20 percent aq. hydrochloric acid / 1 h / Heating

With hydrogenchloride; ammonia; In methanol; 1: Mannich reaction;

DOI:10.1002/ejoc.200300753

Reference yield:

2,4-bis-(3-bromo-phenyl)-3,4-dihydro-2H-naphtho[2,1-e][1,3]oxazine → 2-(α-amino-3-bromobenzyl)-1-naphthol hydrochloride (736173-15-2)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1002/ejoc.200300753

upstream raw materials:

α-naphthol