Trifarotene

Base Information

Chemical Name:Trifarotene
CAS No.:895542-09-3
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:
UNII:0J8RN2W0HK
ChEMBL ID:CHEMBL3707313
DSSTox Substance ID:DTXSID30237781
Metabolomics Workbench ID:153725
NCI Thesaurus Code:C118577
Pharos Ligand ID:W4BXSF5NLJZG
RXCUI:2205637
Wikidata:Q27236856
Wikipedia:Trifarotene

Synonyms:Aklief;CD5789;trifarotene

Suppliers and Price of Trifarotene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Trifarotene
5mg
$ 310.00

TRC
Trifarotene
2.5mg
$ 160.00

CSNpharm
Trifarotene
1mg
$ 192.00

CSNpharm
Trifarotene
10mg
$ 512.00

ChemScene
Trifarotene 99.50%
100mg
$ 2800.00

ChemScene
Trifarotene 99.50%
50mg
$ 1650.00

ChemScene
Trifarotene 99.50%
10mg
$ 550.00

ChemScene
Trifarotene 99.50%
5mg
$ 350.00

AK Scientific
Trifarotene
1mg
$ 292.00

Total 27 raw suppliers

Chemical Property of Trifarotene

Chemical Property:

XLogP3:6.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:459.24095853
Heavy Atom Count:34
Complexity:647

Purity/Quality:

99% ^*data from raw suppliers

Trifarotene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C1=C(C=CC(=C1)C2=C(C=CC(=C2)C3=CC=C(C=C3)C(=O)O)OCCO)N4CCCC4
Recent ClinicalTrials:AkLief Evaluation in Acne-induced Post-Inflammatory Hyperpigmentation
Recent EU Clinical Trials:Evaluation of acne-induced hyperpigmentation during treatment of acne vulgaris subjects with trifarotene 50 μg/g cream versus vehicle cream over 24 weeks.
Uses Trifarotene, is a retinoic acid receptor (RAR) agonist.

Technology Process of Trifarotene

There total 10 articles about Trifarotene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2-((3''-(tert-butyl)-4-cyano-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4'-yl)oxy)ethyl acetate

: 895542-09-3
3″-tert-butyl-4′-(2-hydroxy-ethoxy)-4″-pyrrolidin-1-yl-[1,1′;3′,1″]-terphenyl-4-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; for 15h; Reflux;

Reference yield: 55.0%

: 895542-09-3
3″-tert-butyl-4′-(2-hydroxy-ethoxy)-4″-pyrrolidin-1-yl-[1,1′;3′,1″]-terphenyl-4-carboxylic acid

Guidance literature:

Reference yield:

: 3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carbonitrile

: 895542-09-3
3″-tert-butyl-4′-(2-hydroxy-ethoxy)-4″-pyrrolidin-1-yl-[1,1′;3′,1″]-terphenyl-4-carboxylic acid

Guidance literature:: 3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carbonitrile; With ethanol; sodium hydroxide; Reflux;

With hydrogenchloride; In water; at 20 ℃; for 2h; pH=4.7;