C₁₄H₁₆O₂

Base Information

• Chemical Name: C₁₄H₁₆O₂
• CAS No.: 1612145-76-2
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.28
• Mol file: 1612145-76-2.mol

Synonyms:

Chemical Property of C₁₄H₁₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₆O₂

There total 1 articles about C₁₄H₁₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-but-3-yn-2-ol (115-19-5) + 1-bromo-2-(o-methoxyphenyl)ethylene (203176-36-7) → C14H16O2 (1612145-76-2)

Guidance literature:

1-bromo-2-(o-methoxyphenyl)ethylene; With palladium diacetate; triphenylphosphine; copper(I) bromide; at 20 ℃; Inert atmosphere;

2-methyl-but-3-yn-2-ol; With piperidine; at 50 ℃; for 0.5h; Inert atmosphere;

With lithium bromide; for 1.5h; Inert atmosphere;

DOI:10.1021/jo5005839

Reference yield:

C14H16O2 (1612145-76-2) → (E)-1-(but-1-en-3-yn-1-yl)-2-methoxybenzene (23517-08-0)

Guidance literature:

With potassium hydroxide; In toluene; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/jo5005839

Reference yield:

C14H16O2 (1612145-76-2) → (R,E)-6-(2-methoxyphenyl)-2-phenylhex-5-en-3-yn-2-ol (1612145-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / toluene / 1 h / Inert atmosphere; Reflux

2.1: (S)-3,3′-bis(4-biphenyl)-2,2′-dihydroxy-1,1′-dinaphthyl / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.33 h / -78 °C / Inert atmosphere

2.3: 120 h / -78 °C / Inert atmosphere

With potassium hydroxide; (S)-3,3′-bis(4-biphenyl)-2,2′-dihydroxy-1,1′-dinaphthyl; In tetrahydrofuran; toluene;

DOI:10.1021/jo5005839

upstream raw materials:

2-methyl-but-3-yn-2-ol

1-bromo-2-(o-methoxyphenyl)ethylene

Downstream raw materials:

(E)-1-(but-1-en-3-yn-1-yl)-2-methoxybenzene

(R,E)-6-(2-methoxyphenyl)-2-phenylhex-5-en-3-yn-2-ol