23517-08-0

Upstream product

• 1457-42-7 pyridazinyl-N-oxide 
• 578-57-4 2-bromoanisole 
• 203176-36-7 1-bromo-2-(o-methoxyphenyl)ethylene 
• 1612145-76-2 C₁₄H₁₆O₂ 

Downstream Products

• 1612145-41-1 (R,E)-6-(2-methoxyphenyl)-2-phenylhex-5-en-3-yn-2-ol 
• 1597418-21-7 (E)-N-butyl-N-(4-(2-methoxyphenyl)but-3-en-1-yn-1-yl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Lithium binaphtholate-catalyzed enantioselective enyne addition to ketones: Access to enynylated tertiary alcohols

A new catalytic enantioselective enyne addition to ketones has been developed. In the presence of chiral lithium binaphtholate, the addition reaction proceeded smoothly to produce a series of enynylated tertiary alcohols in up to 96% yield and 94% enantiomeric excess. Convenient transformation of the adduct via Pauson-Khand cycloaddition reaction afforded the bicyclic product without detectable loss of enantioselectivity. Furthermore, catalytic asymmetric enyne addition to trifluoromethylketone was applied in the synthesis of the Efavirenz analogue.