5-(4'-Hydroxyphenyl)-5-phenylhydantoin

Base Information

• Chemical Name: 5-(4'-Hydroxyphenyl)-5-phenylhydantoin
• CAS No.: 57464-82-1
• Molecular Formula: C₁₅H₁₂N₂O₃
• Molecular Weight: 268.272
• Mol file: 57464-82-1.mol

Synonyms:

Chemical Property of 5-(4'-Hydroxyphenyl)-5-phenylhydantoin

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

5-(4-Hydroxyphenyl)-5-phenylhydantoin 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4'-Hydroxyphenyl)-5-phenylhydantoin

There total 9 articles about 5-(4'-Hydroxyphenyl)-5-phenylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(4-methoxyphenyl)-5-phenylimidazolidine-2,4-dione (17816-50-1) → 5-(4-hydroxyphenyl)-5-phenylhydantoin (2784-27-2,57464-82-1)

Guidance literature:

With aluminium trichloride; In various solvent(s); at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2004.07.007

Reference yield: 59.0%

5-(4-hydroxyphenyl)-5-phenylhydantoin (2784-27-2,57464-82-1) → 4'-(S)-hydroxyphenytoin (57496-20-5,57464-82-1)

Guidance literature:

With sodium hydroxide; brucine; In methanol; Heating;

DOI:10.1016/j.tetasy.2004.07.007

Reference yield: 44.0%

ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 4-Hydroxybenzophenone (1137-42-4) → 5-(4-hydroxyphenyl)-5-phenylhydantoin (2784-27-2,57464-82-1)

Guidance literature:

With potassium cyanide; In ethanol; water; at 120 ℃; for 18h;

DOI:10.1016/j.tetasy.2004.07.007

upstream raw materials:

potassium cyanide

ammonium bicarbonate

4-Hydroxybenzophenone

phenythoin

Refernces

• 1、 Mays, Dennis C.,Pawluk, Lew J.,Apseloff, Glen,Davis, W. Bruce,She, Zhi-Wu,Sagone, Arthur L.,Gerber, Nicholas. "Metabolism of Phenytoin and Covalent Binding of Reactive Intermediates in Activated Human Neutrophils". . p. 367 - 380. Retrieved 2007/10/03.
• 2、 Kasuya,Mamada,Baba,Matsukura. "Stable-isotope methodology for the bioavailability study of phenytoin during multiple-dosing regimens". . p. 503 - 507. Retrieved 2007/10/02.