deoxynyboquinone

Base Information

• Chemical Name: deoxynyboquinone
• CAS No.: 96748-86-6
• Molecular Formula: C₁₅H₁₂N₂O₄
• Molecular Weight: 284.271
• Mol file: 96748-86-6.mol

Synonyms:

Chemical Property of deoxynyboquinone

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Deoxynyboquinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Deoxynyboquinone is an anticancer agent that induces cancer cell death. Deoxynyboquinone and its derivatives can be utilized to develop selective anticancer therapy.

Technology Process of deoxynyboquinone

There total 9 articles about deoxynyboquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diazaanthracenol (30408-37-8) → deoxynyboquinone (96748-86-6)

Guidance literature:

With oxygen; cobalt(II)(bis(salicylidene)ethylenediamine); In methanol; dichloromethane; at 20 ℃; for 2.75h;

DOI:10.1021/ja100610m

Reference yield:

(4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane) (1221589-81-6) → deoxynyboquinone (96748-86-6)

Guidance literature:

Multi-step reaction with 7 steps

1: Iodine monochloride / dichloromethane / 20 °C / Cooling with ice

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24.08 h / 80 °C / Inert atmosphere; Schlenk technique

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,2-dimethoxyethane; water / 2.5 h / 90 °C / Inert atmosphere

4: potassium carbonate; XPhos / isopropyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

5: hydrogen bromide / 0.08 h / 110 °C

6: hydrogen bromide / 110 °C

7: salcomine; oxygen / methanol; dichloromethane / 2.75 h / 23 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; salcomine; hydrogen bromide; oxygen; potassium acetate; Iodine monochloride; potassium carbonate; XPhos; In methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 4: |Suzuki Coupling;

Reference yield:

C24H26Cl2N2O4 (1430798-63-2) → deoxynyboquinone (96748-86-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; XPhos / isopropyl alcohol / 15 h / 110 °C / Inert atmosphere; Sealed tube

2: hydrogen bromide / 0.08 h / 110 °C

3: hydrogen bromide / 110 °C

4: salcomine; oxygen / methanol; dichloromethane / 2.75 h / 23 °C

With salcomine; hydrogen bromide; oxygen; potassium carbonate; XPhos; In methanol; dichloromethane; isopropyl alcohol; 1: |Suzuki Coupling;

upstream raw materials:

diazaanthracenol

(4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane)

C₂₄H₂₆Cl₂N₂O₄

C₂₄H₂₄N₂O₄