GDC-0077

Base Information

• Chemical Name: GDC-0077
• CAS No.: 2060571-02-8
• Molecular Formula: C₁₈H₁₉F₂N₅O₄
• Molecular Weight: 407.377
• Mol file: 2060571-02-8.mol

Synonyms:

Chemical Property of GDC-0077

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

GDC-0077 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GDC-0077

There total 12 articles about GDC-0077 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ammonium (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propionate → (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (2060571-02-8)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; at 10 ℃; for 20h; Large scale;

Reference yield: 46.0%

L-alanin (56-41-7,25191-17-7,18875-37-1) + (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one → (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (2060571-02-8)

Guidance literature:

L-alanin; (S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one; With potassium phosphate; In dimethyl sulfoxide; at 100 ℃; for 2h;

With ammonium chloride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃; for 1.08333h;

Reference yield:

9-bromo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine (1282516-67-9) → (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (2060571-02-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 12 h / 60 °C / Large scale

2.1: n-propylmagnesium bromide / diethyl ether / 6.5 h / -20 - -15 °C / Inert atmosphere

3.1: (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide; potassium carbonate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

4.1: potassium phosphate / dimethyl sulfoxide / 2 h / 100 °C

4.2: 1.08 h / 20 °C

With potassium phosphate; N-iodo-succinimide; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; n-propylmagnesium bromide; potassium carbonate; In 1,4-dioxane; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

9-bromo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine

9-bromo-2,3-diiodo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine

9-bromo-2-iodo-5,6-dihydrobenzo[f ]imidazo[1,2-d][1,4]oxazepine

3-Bromophenol