2-(6-Phenoxy-pyridin-3-yl)-ethylamine

Base Information

• Chemical Name: 2-(6-Phenoxy-pyridin-3-yl)-ethylamine
• CAS No.: 910400-48-5
• Molecular Formula: C₁₃H₁₄N₂O
• Molecular Weight: 214.267
• Mol file: 910400-48-5.mol

Synonyms:

Chemical Property of 2-(6-Phenoxy-pyridin-3-yl)-ethylamine

Chemical Property:

Purity/Quality:

2-(6-Phenoxy-pyridin-3-yl)-ethylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-Phenoxy-pyridin-3-yl)-ethylamine

There total 6 articles about 2-(6-Phenoxy-pyridin-3-yl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H10N2O → C13H14N2O (910400-48-5)

Guidance literature:

With ammonium hydroxide; hydrogen; In ethanol; at 20 ℃;

DOI:10.1021/acs.jafc.6b05580

Reference yield:

6-Chloronicotinic acid methyl ester (73781-91-6) → C13H14N2O (910400-48-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 10 h / 100 °C

2.1: Red-Al / diethyl ether; toluene / 4 h / 0 - 20 °C

2.2: 2 h / 0 - 35 °C

3.1: thionyl chloride / dichloromethane / 4 h / 0 - 20 °C

4.1: 18-crown-6 ether / dimethyl sulfoxide / 2 h / 40 - 80 °C

5.1: ammonium hydroxide; hydrogen / ethanol / 20 °C

With ammonium hydroxide; thionyl chloride; 18-crown-6 ether; hydrogen; sodium hydride; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jafc.6b05580

Reference yield:

phenol (108-95-2,27073-41-2) → C13H14N2O (910400-48-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

1.2: 10 h / 100 °C

2.1: Red-Al / diethyl ether; toluene / 4 h / 0 - 20 °C

2.2: 2 h / 0 - 35 °C

3.1: thionyl chloride / dichloromethane / 4 h / 0 - 20 °C

4.1: 18-crown-6 ether / dimethyl sulfoxide / 2 h / 40 - 80 °C

5.1: ammonium hydroxide; hydrogen / ethanol / 20 °C

With ammonium hydroxide; thionyl chloride; 18-crown-6 ether; hydrogen; sodium hydride; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jafc.6b05580

upstream raw materials:

6-Chloronicotinic acid methyl ester

phenol

2-phenoxy-5-pyridylmethyl chloride

(6-phenoxy-pyridin-3-yl)-methanol

Refernces