2-(1H-BENZOIMIDAZOL-2-YL)-QUINOLINE

Base Information

• Chemical Name: 2-(1H-BENZOIMIDAZOL-2-YL)-QUINOLINE
• CAS No.: 14044-48-5
• Molecular Formula: C16H11N3
• Molecular Weight: 245.283
• Mol file: 14044-48-5.mol

Synonyms:2-(2-quinolyl)benzimidazole;2-(1H-Benzo[d]imidazol-2-yl)quinoline;2-(benzimidazol-2-yl)quinoline;2-(1H-Benzoimidazol-2-yl)-quinoline;2-(2-quinolinyl)benzimidazole;2-benzo[d]imidazol-2-yl-quinoline;

Chemical Property of 2-(1H-BENZOIMIDAZOL-2-YL)-QUINOLINE

Chemical Property:

• PSA: 41.57000
• LogP: 3.77810
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(1H-Benzo[d]imidazol-2-yl)quinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• General Description: **Conclusion:** 2-(1H-Benzoimidazol-2-yl)-quinoline (L1) is a bidentate benzimidazole-based ligand derived from quinoline-2-carboxylic acid. It has been utilized in the synthesis of Ru(II) complexes, such as [RuCl(L1)(p-cymene)]PF₆ (C1), which exhibit catalytic activity in oxidation reactions (e.g., benzyl alcohol to benzaldehyde) and potential applications in transfer hydrogenation. Additionally, derivatives of this scaffold have been explored for cytotoxic activity against cancer cell lines, demonstrating its versatility in coordination chemistry and medicinal chemistry.

Technology Process of 2-(1H-BENZOIMIDAZOL-2-YL)-QUINOLINE

There total 11 articles about 2-(1H-BENZOIMIDAZOL-2-YL)-QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

quinoline 2-carbaldehyde (5470-96-2) + 1,2-diamino-benzene (95-54-5) → 2-(2-quinolyl)benzimidazole (14044-48-5)

Guidance literature:

In water; at 60 ℃; for 1h; Sonication;

DOI:10.1039/d0dt03107k

Reference yield: 94.0%

2-methylquinoline (91-63-4) + 1,2-diamino-benzene (95-54-5) → 2-(2-quinolyl)benzimidazole (14044-48-5)

Guidance literature:

With iodine; oxygen; In dimethyl sulfoxide; at 110 ℃; Reagent/catalyst;

DOI:10.1016/j.tetlet.2017.04.007

Reference yield: 92.0%

quinoline-2-carboxylic acid (93-10-7,1199266-78-8) + 1,2-diamino-benzene (95-54-5) → 2-(2-quinolyl)benzimidazole (14044-48-5)

Guidance literature:

With polyphosphoric acid; at 160 ℃; for 24h;

DOI:10.1007/s12039-016-1210-1

upstream raw materials:

2-methylquinoline

1,2-diamino-benzene

quinoline 2-carbaldehyde

quinoline-2-carboxylic acid

Downstream raw materials:

2-[1-(2-Pyridin-4-yl-ethyl)-1H-benzoimidazol-2-yl]-quinoline

Cu(2-(2-quinolyl)benzimidazole)(bis(2-diphenylphosphinophenyl)ether)BF₄

Cu(2-(2-quinolyl)benzimidazole)(PPh₃)2BF₄

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