cabozantinib-N-oxide

Base Information

• Chemical Name: cabozantinib-N-oxide
• CAS No.: 1621681-63-7
• Molecular Formula: C₂₈H₂₄FN₃O₆
• Molecular Weight: 517.513
• Mol file: 1621681-63-7.mol

Synonyms:

Chemical Property of cabozantinib-N-oxide

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

CabozantinibN-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.

Technology Process of cabozantinib-N-oxide

There total 6 articles about cabozantinib-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid (849217-48-7) + C17H16N2O4 → cabozantinib-N-oxide (1621681-63-7)

Guidance literature:

((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

C₁₇H₁₆N₂O₄; In N,N-dimethyl-formamide; at 35 ℃; for 3h;

Reference yield:

cabozantinib (849217-68-1) → cabozantinib-N-oxide (1621681-63-7)

Guidance literature:

With sodium peroxoborate tetrahydrate; acetic acid; at 65 ℃;

Reference yield:

cyclopropane-1,1-dicarboxylic acid (598-10-7) → cabozantinib-N-oxide (1621681-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / ethyl acetate / 1 h / 0 - 10 °C / Large scale

1.2: 1 h / 10 °C / Large scale

2.1: ethyl acetate / 16 h / 10 °C / Large scale

3.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 3 h / 35 °C

With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); triethylamine; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

cabozantinib

((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

cyclopropane-1,1-dicarboxylic acid

1-(chlorocarbonyl)cyclopropane-1-carboxylic acid