(2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride

Base Information

• Chemical Name: (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride
• CAS No.: 365280-18-8
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Hs Code.: 2933998090
• Mol file: 365280-18-8.mol

Synonyms:

Chemical Property of (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

trans-4-Methyl-L-prolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: trans-4-Methyl-L-proline Hydrochloride is an analog of L-Proline (P755995); an α-amino acid and precursor (with vitamin C) for collagen which is the building block of the structure of tendons, ligaments, arteries, veins and muscles. Also important in wound healing.

Technology Process of (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride

There total 14 articles about (2S,4R)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ (2S,4S)-4-methylpyrrolidine-2-carboxylic acid hydrochloride (201481-62-1,365280-18-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h;

Reference yield: 94.0%

tert-butyl (2S,4S)-N-tert-butoxycarbonyl-4-methylprolinate (159415-73-3) → (2S,4S)-4-methylpyrrolidine-2-carboxylic acid hydrochloride (201481-62-1,365280-18-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/0040-4039(94)85381-9

Reference yield: 55.0%

N-Boc-4-methyl-L-proline (871727-77-4) → trans-4-methyl-L-proline hydrochloride (365280-18-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00781

upstream raw materials:

tert-butyl (2S,4S)-N-tert-butoxycarbonyl-4-methylprolinate

(2S,4S)-di-tert-butyl 4-methyl-5-oxopyrrolidine-1,2-dicarboxylate

N-CBz-trans-4-methyl-L-proline ethyl ester

cis-4-methyl-L-proline ethyl ester

Downstream raw materials:

(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-methylpyrrolidine-2-carboxylic acid

Refernces

• 1、 Goodreid, Jordan D.,Dos Santos Da Silveira, Eduardo,Batey, Robert A.. "A lanthanide(III) triflate mediated macrolactonization/solid-phase synthesis approach for depsipeptide synthesis". supporting information. p. 2182 - 2185. Retrieved 2015/05/13.
• 2、 -. "1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives". Paragraph 0109; 0123; 0124. . Retrieved 2014/05/24.