2,6-Difluoro-3-methoxybenzyl alcohol

Base Information

• Chemical Name: 2,6-Difluoro-3-methoxybenzyl alcohol
• CAS No.: 886498-45-9
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.147
• Hs Code.: 2909498090
• DSSTox Substance ID: DTXSID401287732
• Mol file: 886498-45-9.mol

Synonyms:2,6-Difluoro-3-methoxybenzyl alcohol;886498-45-9;(2,6-difluoro-3-methoxyphenyl)methanol;SCHEMBL4399022;XNWNGHHOEXEHCR-UHFFFAOYSA-N;DTXSID401287732;MFCD04115904;2,6-Difluoro-3-methoxybenzenemethanol;AKOS006292130;JS-4264;SB84586;CS-0193829;C90763

Chemical Property of 2,6-Difluoro-3-methoxybenzyl alcohol

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 174.04923582
• Heavy Atom Count: 12
• Complexity: 143

Purity/Quality:

98% ^*data from raw suppliers

2,6-Difluoro-3-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)F)CO)F

Technology Process of 2,6-Difluoro-3-methoxybenzyl alcohol

There total 1 articles about 2,6-Difluoro-3-methoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,6-difluoro-3-methoxybenzaldehyde (149949-30-4) → (2,6-difluoro-3-methoxyphenyl)methanol (886498-45-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.5h;

Reference yield:

(2,6-difluoro-3-methoxyphenyl)methanol (886498-45-9) → {1-[({7-[(2,6-difluoro-3-methoxybenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridin-3-yl}carbonyl)amino]-2-methylpentan-2-yl}carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

With thionyl chloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(2,6-difluoro-3-methoxyphenyl)methanol (886498-45-9) → N-(2-amino-2-methylpentyl)-7-[(2,6-difluoro-3-methoxybenzyl)oxy]-2,5-dimethylpyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With thionyl chloride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,6-difluoro-3-methoxybenzaldehyde

Refernces