4-methoxy-N',N'-diphenylbenzohydrazide

Base Information

• Chemical Name: 4-methoxy-N',N'-diphenylbenzohydrazide
• CAS No.: 304668-43-7
• Molecular Formula: C₂₀H₁₈N₂O₂
• Molecular Weight: 318.375
• Mol file: 304668-43-7.mol

Synonyms:

Chemical Property of 4-methoxy-N',N'-diphenylbenzohydrazide

Chemical Property:

Purity/Quality:

4-methoxy-N',N'-diphenylbenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-N',N'-diphenylbenzohydrazide

There total 3 articles about 4-methoxy-N',N'-diphenylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methoxy-N'-phenylbenzohydrazide (15089-03-9) → 4-methoxy-N',N'-diphenylbenzohydrazide (304668-43-7)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate monohydrate; triethylamine; In methanol; at 20 ℃; regioselective reaction;

DOI:10.1039/c4ob02343a

Reference yield:

4-methoxybenzoic acid (100-09-4) + benzoic acid (65-85-0,8013-63-6) → 4-methoxy-N',N'-diphenylbenzohydrazide (304668-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: copper(II) acetate monohydrate; 1,10-Phenanthroline; triethylamine / methanol / 20 °C

With 1,10-Phenanthroline; copper(II) acetate monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c4ob02343a

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + 1,1-Diphenylhydrazine (530-50-7) → 4-methoxy-N',N'-diphenylbenzohydrazide (304668-43-7)

Guidance literature:

With diethyl ether;

upstream raw materials:

4-methoxy-benzoyl chloride

1,1-Diphenylhydrazine

4-methoxybenzoic acid

benzoic acid

Refernces

• 1、 Wang, Wei-Juan,Zhang, Ting,Duan, Li-Jun,Zhang, Xue-Jing,Yan, Ming. "KOt-Bu promoted homocoupling and decomposition of N'-aryl acylhydrazines: synthesis of unsymmetric N',N'-diaryl acylhydrazines". . p. 9073 - 9080. Retrieved 2015/11/09.