RY83F5VR5B

Base Information

• Chemical Name: RY83F5VR5B
• CAS No.: 3258-09-1
• Molecular Formula: C₁₀H₁₄N₂O₆
• Molecular Weight: 258.231
• UNII: RY83F5VR5B
• Mol file: 3258-09-1.mol

Synonyms:RY83F5VR5B;UNII-RY83F5VR5B;1-(alpha-D-Ribofuranosyl)thymine;Thymine, 1-alpha-D-ribofuranosyl-;1-(alpha-D-Ribofuranosyl)thymine [MI];3258-09-1;2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-alpha-D-ribofuranosyl-;1-(.ALPHA.-D-RIBOFURANOSYL)THYMINE;THYMINE, 1-.ALPHA.-D-RIBOFURANOSYL-;1-(.ALPHA.-D-RIBOFURANOSYL)THYMINE [MI];2,4(1H,3H)-PYRIMIDINEDIONE, 5-METHYL-1-.ALPHA.-D-RIBOFURANOSYL-

Chemical Property of RY83F5VR5B

Chemical Property:

• XLogP3: -1.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 258.08518617
• Heavy Atom Count: 18
• Complexity: 409

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
• Isomeric SMILES: CC1=CN(C(=O)NC1=O)[C@@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

Technology Process of RY83F5VR5B

There total 6 articles about RY83F5VR5B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1-(2-carboethoxyallyl)-α-D-ribofurano<1',2':4,5>-2-oxazoliminium bromide → 2,2'-anhydro-1-α-D-ribofuranosylthymine (55177-07-6) + α-thymidine (3258-09-1,642082-80-2)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 30 ℃; for 72h;

DOI:10.1080/15257779408012178

Reference yield:

2-amino-(1,2-dideoxy-α-D-ribofurano)<1,2-d>-2-oxazoline (27963-97-9) → α-thymidine (3258-09-1,642082-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / dimethylacetamide / Ambient temperature

2: 34 percent / t-BuOK / 2-methyl-propan-2-ol / 72 h / 30 °C

3: aq. NH₄OH

With ammonium hydroxide; ISOPROPYLAMIDE; potassium tert-butylate; In tert-butyl alcohol;

DOI:10.1080/15257779408012178

Reference yield:

2,4-diethoxy-5-methylpyrimidine (7193-87-5) → α-thymidine (3258-09-1,642082-80-2)

Guidance literature:

anschliessende Hydrolyse mit HCl enthaltendem Methanol;

DOI:10.1021/ja01123a026

upstream raw materials:

2,2'-anhydro-1-α-D-ribofuranosylthymine

2,4-diethoxy-5-methylpyrimidine

2-amino-(1,2-dideoxy-α-D-ribofurano)<1,2-d>-2-oxazoline