Lipoamido-PEG2-alcohol

Base Information

• Chemical Name: Lipoamido-PEG2-alcohol
• CAS No.: 1674386-82-3
• Molecular Formula: C₁₄H₂₇NO₄S₂
• Molecular Weight: 337.505
• Mol file: 1674386-82-3.mol

Synonyms:

Chemical Property of Lipoamido-PEG2-alcohol

Chemical Property:

• Boiling Point: 546.5±35.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.163±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Lipoamido-PEG2-alcohol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Lipoamido-PEG2-alcohol is a linker with lipoamide moiety and a reactive alcohol group. The alcohol group can react to further derivatize the compound. The hydrophilic PEG sparcer increases the compound's water solublility in aqueous media.

Technology Process of Lipoamido-PEG2-alcohol

There total 2 articles about Lipoamido-PEG2-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H41NO4S2Si → N-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-5-(1,2-dithiolan-3-yl)pentanamide (1674386-82-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2018.04.049

Reference yield:

2-(2-(2-tert-butyldimethylsilyloxyethoxy)ethoxy)ethylamine + Thioctic acid (1077-28-7,62-46-4) → N-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-5-(1,2-dithiolan-3-yl)pentanamide (1674386-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: immobilized Candida antarctica Lipase B / 1,4-dioxane; water / 72 h / 50 °C / Sealed tube; Enzymatic reaction

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With immobilized Candida antarctica Lipase B; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1016/j.tetlet.2018.04.049

upstream raw materials:

Thioctic acid

Refernces