3,4,5-Trifluorophenylacetyl chloride

Base Information

• Chemical Name: 3,4,5-Trifluorophenylacetyl chloride
• CAS No.: 849623-76-3
• Molecular Formula: C₈H₄ClF₃O
• Molecular Weight: 208.567
• Hs Code.: 2916399090
• Mol file: 849623-76-3.mol

Synonyms:

Chemical Property of 3,4,5-Trifluorophenylacetyl chloride

Chemical Property:

Purity/Quality:

99%min. ^*data from raw suppliers

3,4,5-Trifluorophenylacetylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5-Trifluorophenylacetyl chloride

There total 1 articles about 3,4,5-Trifluorophenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4,5-trifluorophenyl)acetic acid (209991-62-8) → C8H4ClF3O (849623-76-3)

Guidance literature:

With pyridine; thionyl chloride;

Reference yield:

C8H4ClF3O (849623-76-3) → 3-(3,4,5-trifluorophenyl)coumarin-7-O-sulfamate

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 4 h / Reflux

2: N,N-dimethyl acetamide / 20 °C

With N,N-dimethyl acetamide; potassium carbonate; In acetone;

DOI:10.1111/cbdd.12652

Reference yield:

C8H4ClF3O (849623-76-3) → C16H15F3N2O4S

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone

2: sulphamoyl chloride / N,N-dimethyl acetamide

With sulphamoyl chloride; potassium carbonate; In N,N-dimethyl acetamide; acetone;

DOI:10.1111/cbdd.12931

upstream raw materials:

2-(3,4,5-trifluorophenyl)acetic acid

Refernces

• 1、 Da?ko, Mateusz,Przyby?owska, Maja,Rachon, Janusz,Mas?yk, Maciej,Kubiński, Konrad,Misiak, Majus,Sk?adanowski, Andrzej,Demkowicz, Sebastian. "Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors". . p. 79 - 87. Retrieved 2017/02/05.
• 2、 Demkowicz, Sebastian,Dako, Mateusz,Kozak, Witold,Krawczyk, Katarzyna,Witt, Dariusz,Maslyk, Maciej,Kubiski, Konrad,Rachon, Janusz. "Synthesis and Biological Evaluation of Fluorinated 3-Phenylcoumarin-7-O-Sulfamate Derivatives as Steroid Sulfatase Inhibitors". . p. 233 - 238. Retrieved 2016/02/14.