isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate

Base Information

• Chemical Name: isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate
• CAS No.: 2389149-74-8
• Molecular Formula: C₄H₆O₄*C₃₂H₃₉N₇O₄
• Molecular Weight: 703.795

Synonyms:

Chemical Property of isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Mobocertinib(succinate) 99.61% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate

There total 8 articles about isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

succinic acid (110-15-6) + AP-32788 → isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate (2389149-74-8)

Guidance literature:

In ethanol; at 10 - 75 ℃; for 6h; Solvent; Temperature;

Reference yield:

2-((4-(2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)amino-4-(1-methyl-1H-indole-3-yl)pyrimidine-5-carboxylic acid isopropyl ester → isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate (2389149-74-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / 2-methyltetrahydrofuran / 11 h / 40 °C / 310.3 - 517.16 Torr / Large scale

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 2 °C / Large scale

2.2: 1.75 h / 0 - 30 °C / Large scale

3.1: potassium trimethylsilonate / tetrahydrofuran / 1 h / -1 - 10 °C / Large scale

4.1: ethanol / 6 h / 10 - 75 °C

With palladium 10% on activated carbon; potassium trimethylsilonate; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; dichloromethane;

Reference yield:

2-(5-amino-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino-4-(1-methyl-1H-indole-3-yl)pyrimidine-5-carboxylic acid isopropyl ester → isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl) (methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate monosuccinate (2389149-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 2 °C / Large scale

1.2: 1.75 h / 0 - 30 °C / Large scale

2.1: potassium trimethylsilonate / tetrahydrofuran / 1 h / -1 - 10 °C / Large scale

3.1: ethanol / 6 h / 10 - 75 °C

With potassium trimethylsilonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

succinic acid

2,4-dichloropyrimidine-5-carboxylic acid isopropyl ester

1-methylindole

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