Biotin-PEG3-propionic acid

Base Information

• Chemical Name: Biotin-PEG3-propionic acid
• CAS No.: 252881-76-8
• Molecular Formula: C₁₉H₃₃N₃O₇S
• Molecular Weight: 447.553
• Hs Code.: 2918999090
• Mol file: 252881-76-8.mol

Synonyms:

Chemical Property of Biotin-PEG3-propionic acid

Chemical Property:

• Boiling Point: 770.7±60.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• Density: 1?+-.0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Biotin-PEG3-propionic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Biotin-PEG3-acid is a biotinylation reagent that can react with amine attached molecule. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein or macromolecule.

Technology Process of Biotin-PEG3-propionic acid

There total 9 articles about Biotin-PEG3-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C23H41N3O7S → biotin-PEG3-acid (252881-76-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 85.0%

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) + biotin (58-85-5,22879-79-4) → biotin-PEG3-acid (252881-76-8)

Guidance literature:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate; biotin; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

With chlorotriisopropylsilane; trifluoroacetic acid; In water;

Reference yield:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate (252881-74-6,872340-65-3) → biotin-PEG3-acid (252881-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

With trifluoroacetic acid; In dichloromethane;

upstream raw materials:

tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate

biotin

biotin N-Hydroxysuccinimide ester

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

2,5-dioxopyrrolidin-1-yl 14-oxo-18-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-13-azaoctadecanoate

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