N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Base Information

Chemical Name:N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide
CAS No.:1629052-78-3
Molecular Formula:C₂₁H₂₃N₃O₆
Molecular Weight:413.43
Hs Code.:

Synonyms:

Suppliers and Price of N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
KZR-504 98.82%
100mg
$ 3850.00

ChemScene
KZR-504 98.82%
25mg
$ 1650.00

ChemScene
KZR-504 98.82%
5mg
$ 450.00

Total 0 raw suppliers

Chemical Property of N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Chemical Property:

Boiling Point:828.9±65.0 °C(Predicted)
Density:1.362±0.06 g/cm3(Predicted)

Purity/Quality:: KZR-504 98.82% ^*data from reagent suppliers

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Technology Process of N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

There total 4 articles about N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1S)-2-[[(1S)-1-benzyl-2-[(2R)-2-methyloxiran-2-yl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]ammonium TFA salt

: 19621-92-2
2-oxo-1,2-dihydropyridine-6-carboxylic acid

: 1629052-78-3
N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: [(1S)-2-[[(1S)-1-benzyl-2-[(2R)-2-methyloxiran-2-yl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]ammonium TFA salt; 2-oxo-1,2-dihydropyridine-6-carboxylic acid; In ethyl acetate; at 0 ℃; for 0.25h;

With 2,6-dimethylpyridine; N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(morpholin-4-yl)methylene]-N-methylmethanaminium hexafluorophosphate; In ethyl acetate; for 0.333333h;
DOI:10.1021/acsmedchemlett.6b00496

Reference yield:

: 1148157-29-2
(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

: 1629052-78-3
N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 0.02 h / 20 °C

2.1: dichloromethane / 0.25 h / 20 °C

3.1: ethyl acetate / 0.25 h / 0 °C

3.2: 0.33 h

With N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/acsmedchemlett.6b00496

Reference yield:

: tert-butyl N-[(1S)-2-[[(1S)-1-benzyl-2-[(2R)-2-methyloxiran-2-yl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamate

: 1629052-78-3
N-((S)-3-hydroxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.25 h / 20 °C

2.1: ethyl acetate / 0.25 h / 0 °C

2.2: 0.33 h

In dichloromethane; ethyl acetate;
DOI:10.1021/acsmedchemlett.6b00496