Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)-

Base Information

• Chemical Name: Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)-
• CAS No.: 140477-37-8
• Molecular Formula: C26H22
• Molecular Weight: 334.461
• DSSTox Substance ID: DTXSID70453206
• Nikkaji Number: J834.075G
• Wikidata: Q82274288
• Mol file: 140477-37-8.mol

Synonyms:140477-37-8;Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)-;1,2,4,5-tetramethyl-3,6-bis(2-phenylethynyl)benzene;1,2,4,5-Tetramethyl-3,6-bis(phenylethynyl)benzene;Benzene, 1,2,4,5-tetramethyl-3,6-bis(2-phenylethynyl)-;((2,3,5,6-Tetramethyl-1,4-phenylene)bis(ethyne-2,1-diyl))dibenzene;YSZC419;DTXSID70453206

Chemical Property of Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)-

Chemical Property:

• PSA: 0.00000
• LogP: 5.71980
• XLogP3: 7.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 4
• Exact Mass: 334.172150702
• Heavy Atom Count: 26
• Complexity: 505

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=C(C(=C1C#CC2=CC=CC=C2)C)C)C#CC3=CC=CC=C3)C

Technology Process of Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)-

There total 2 articles about Benzene, 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,4-diiodo-2,3,5,6-tetramethylbenzene (3268-21-1) + phenylacetylene (536-74-3) → 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)benzene (140477-37-8)

Guidance literature:

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; for 36h; Inert atmosphere;

DOI:10.1021/ja3019065

Reference yield:

1,2,4,5-tetramethylbenzene (95-93-2) → 1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)benzene (140477-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; mercuric triflate / dichloromethane

2: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 36 h / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; mercuric triflate; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;

DOI:10.1021/ja3019065

Reference yield: 77.0%

1,2,4,5-tetramethyl-3,6-bis(phenylethynyl)benzene (140477-37-8) → Duroquinone (527-17-3,70128-24-4) + 1,1'-diphenyl-2,2'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(ethanedione) (106877-53-6) + 6-(1,2-dioxo-2-phenylethyl)-1,2,4,5-tetramethyl-3-(phenylethynyl)benzene (140477-39-0) + 1-(4-hydroxy-2,3,5,6-tetramethylphenyl)-2-phenylethanedione

Guidance literature:

With iodine; oxygen; In dimethyl sulfoxide; at 145 ℃; for 5.5h;

DOI:10.1023/A:1011329621330

upstream raw materials:

1,4-diiodo-2,3,5,6-tetramethylbenzene

phenylacetylene

1,2,4,5-tetramethylbenzene

Downstream raw materials:

1,1'-diphenyl-2,2'-(2,3,5,6-tetramethyl-1,4-phenylene)bis(ethanedione)

2,3,5,6-Tetramethyl-4-phenylethynyl-benzoic acid

6-(1,2-dioxo-2-phenylethyl)-1,2,4,5-tetramethyl-3-(phenylethynyl)benzene

Duroquinone