95-93-2

Basic information

• Product Name: 1,2,4,5-Tetramethylbenzene
• Synonyms: p-Xylene,2,5-dimethyl- (7CI);Durene;Durol;NSC 6770
• CAS NO: 95-93-2
• Molecular Formula: C₁₀H₁₄
• Molecular Weight: 134.21816
• EINECS: 202-465-7
• Mol File: 95-93-2.mol
• Article Data: 61

Chemical Properties

• Melting Point: 76-82℃
• Boiling Point: 192 °C at 760 mmHg
• Flash Point: 73.9 °C
• Appearance: white crystalline powder
• Density: 0.868 g/cm³
• Water Solubility: insoluble
• CAS DataBase Reference: 1,2,4,5-Tetramethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4,5-Tetramethylbenzene(95-93-2)
• EPA Substance Registry System: 1,2,4,5-Tetramethylbenzene(95-93-2)

Safety Data

• Hazard Codes: F:Flammable
• Statements: R11:
• Safety Statements: S16:
• Hazardous Substances Data: 95-93-2(Hazardous Substances Data)

Usage

General Description

1,2,4,5-Tetramethylbenzene, also known as 1,2,4,5-tetramethyl-3-ethylbenzene, is a highly flammable organic compound with the chemical formula C10H14. It is a colorless liquid with a sweet odor and is commonly used as a solvent in industrial applications. 1,2,4,5-Tetramethylbenzene is also used as a starting material in the production of various chemicals, including dyes, perfumes, and pharmaceuticals. It is important to handle this chemical with care due to its flammability and potential health hazards, including skin and eye irritation. Additionally, exposure to high levels of 1,2,4,5-tetramethylbenzene may cause dizziness, headaches, and nausea. Therefore, proper safety measures and ventilation are essential when working with this compound.

InChI:InChI=1/C10H14/c1-7-5-9(3)10(4)6-8(7)2/h5-6H,1-4H3

Upstream product

• 67-56-1 methanol 
• 26976-92-1 1,2,4,5-tetramethyl-3,6-dihydrobenzene 
• 2142-79-2 2,3,5,6-tetramethylacetophenone 
• 108-67-8 1,3,5-trimethyl-benzene 
• 108-48-5 2,6-dimethylpyridine 
• 80721-78-4 2,6,9,10-tetracyanoanthracene 
• 139-66-2 diphenylsulfinium radical cation 
• 591-50-4 phenyliodinium radical cation 
• 46010-98-4 2,5-dichloroxyloquinone 
• 5779-72-6 2,4,5-trimethylbenzaldehyde 
• 95-63-6 1,2,4-Trimethylbenzene 
• 2100-25-6 2,3,5,6-tetramethyliodobenzene 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 1074-24-4 2,5-dibromo-p-xylene 

Downstream Products

• 67159-34-6 2,3,5,6-tetramethylphenacyl bromide 
• 40910-07-4 4'-methoxy-2,3,5,6-tetramethyl-benzophenone 
• 64357-79-5 2,3,5,6,2'-pentamethyl-benzophenone 
• 10519-73-0 N-(2,4,5-trimethyl-benzyl)-acetamide 
• 1226954-85-3 10-methylacridinyl radical 
• 92-52-4 biphenyl 
• 104720-28-7 1,4-etheno-1,3-dihydro-2,3,9,10-tetramethylnaphthalene 
• 1217-45-4 9,10-dicyanoanthracene radical anion 
• 107126-13-6 [Methylsulfanyl-(2,3,5,6-tetramethyl-phenyl)-methyl]-phosphonic acid diethyl ester 
• 91390-74-8 1,1-didurylethene 
• 21979-72-6 Bis-(pentamethylbenzyl)-durol 
• 14337-37-2 2,3,5,6-tetramethylanisole 
• 91390-75-9 1,1-didurylpropene 
• 87185-34-0 1,3,4,6-Tetramethyl-7-(1,4-diphenyl-1,2,3-triazol-5-yl)norcaradiene 

Relevant articles and documents

Picosecond Transient Absorption Measurements of Geminate Electron-Cation Recombination

Durene (1,2,4,5-tetramethylbenzene) dissolved in n-hexane was photoionized by 35-ps light pulses at 266 nm.Transient absorption at 1064 nm arising chiefly from geminate electrons was detected and used to monitor the recombination of the electron-cation pairs produced by two-photon ionization.An excellent fit to the recombination kinetics at 208 K was obtained by assuming that the distribution of initial electron-cation separations was of the form r2EXP=r2/(2L3)exp(-r/L) with a mean radius 3L = 5.7 nm.

Coupling of Methanol and Carbon Monoxide over H-ZSM-5 to Form Aromatics

The conversion of methanol into aromatics over unmodified H-ZSM-5 zeolite is generally not high because the hydrogen transfer reaction results in alkane formation. Now circa 80 % aromatics selectivity for the coupling reaction of methanol and carbon monoxide over H-ZSM-5 is reported. Carbonyl compounds and methyl-2-cyclopenten-1-ones (MCPOs), which were detected in the products and catalysts, respectively, are considered as intermediates. The latter species can be synthesized from the former species and olefins. 13C isotope tracing and 13C liquid-state NMR results confirmed that the carbon atoms of CO molecules were incorporated into MCPOs and aromatic rings. A new aromatization mechanism that involves the formation of the above intermediates and co-occurs with a dramatically decreased hydrogen transfer reaction is proposed. A portion of the carbons in CO molecules are incorporated into aromatic, which is of great significance for industrial applications.

Selective Production of Renewable para-Xylene by Tungsten Carbide Catalyzed Atom-Economic Cascade Reactions

Tungsten carbide was employed as the catalyst in an atom-economic and renewable synthesis of para-xylene with excellent selectivity and yield from 4-methyl-3-cyclohexene-1-carbonylaldehyde (4-MCHCA). This intermediate is the product of the Diels–Alder reaction between the two readily available bio-based building blocks acrolein and isoprene. Our results suggest that 4-MCHCA undergoes a novel dehydroaromatization–hydrodeoxygenation cascade process by intramolecular hydrogen transfer that does not involve an external hydrogen source, and that the hydrodeoxygenation occurs through the direct dissociation of the C=O bond on the W2C surface. Notably, this process is readily applicable to the synthesis of various (multi)methylated arenes from bio-based building blocks, thus potentially providing a petroleum-independent solution to valuable aromatic compounds.