4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide
CAS No.:2139382-75-3
Molecular Formula:C₂₈H₂₂F₃N₇O₂
Molecular Weight:545.524
Hs Code.:

Synonyms:

Suppliers and Price of 4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Nilotinib3-ImidazolylN-oxide
50mg
$ 2000.00

TRC
Nilotinib3-ImidazolylN-oxide
25mg
$ 1065.00

TRC
Nilotinib3-ImidazolylN-oxide
5mg
$ 245.00

Total 3 raw suppliers

Chemical Property of 4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Chemical Property:

Melting Point:>156°C (dec.)
Density:1.39±0.1 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

Nilotinib3-ImidazolylN-oxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine is an impurity compound of Nilotinib (N465300), useful in the treatment of chronic myelogenous leukemia. It is a COVID19-related research product.

Technology Process of 4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

There total 5 articles about 4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 641569-94-0
4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid

: 3-(3-oxo-4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

: 2139382-75-3
4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 24h; Inert atmosphere;

Reference yield:

: 641571-11-1
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

: 2139382-75-3
4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 - 35 °C

2: peracetic acid / dichloromethane / 12 h / 20 °C

3: sodium hydroxide / methanol / 5 h / 20 - 50 °C

4: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 20 - 60 °C / Inert atmosphere

With peracetic acid; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: N-(3-(4-methyl-1H-1-imidazolyl)-5-trifluoromethylbenzene) tert-butoxycarbonylamine

: 2139382-75-3
4-methyl-3-([4-(3-pyridyl)-2-pyrimidinyl]amino)-N-[5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 - 35 °C

2: hydrogenchloride / methanol; water / 6 h / 20 - 40 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 24 h / 20 - 60 °C / Inert atmosphere

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;