[3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Base Information

Chemical Name:[3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine
CAS No.:1525641-12-6
Molecular Formula:C₅H₆F₃N₃
Molecular Weight:165.118
Hs Code.:2933199090

Synonyms:

Suppliers and Price of [3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
4-(Aminomethyl)-3-(trifluoromethyl)pyrazole
1 g
$ 885.00

Crysdot
4-(Aminomethyl)-3-(trifluoromethyl)pyrazole 95+%
1g
$ 371.00

Chemenu
4-(Aminomethyl)-3-(trifluoromethyl)pyrazole 95+%
1g
$ 1378.00

Apolloscientific
4-(Aminomethyl)-3-(trifluoromethyl)pyrazole
1g
$ 553.00

AK Scientific
4-(Aminomethyl)-3-(trifluoromethyl)pyrazole
1g
$ 863.00

Total 3 raw suppliers

Chemical Property of [3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-(Aminomethyl)-3-(trifluoromethyl)pyrazole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

There total 5 articles about [3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [1-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]methanamine

: 1525641-12-6
[3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 20 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield:

: 155377-19-8
ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate

: 1525641-12-6
[3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 2 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 30 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

5.1: ammonium cerium (IV) nitrate / acetonitrile; water / 2 h / 20 °C

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydride; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1105039-92-6
ethyl 1-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)pyrazole-4-carboxylate

: 1525641-12-6
[3-(trifluoromethyl)-1H-pyrazol-4-yl]methanamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; water / ethanol / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine; ammonium chloride; benzotriazol-1-ol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 30 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

4: ammonium cerium (IV) nitrate / acetonitrile; water / 2 h / 20 °C

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;