Naltrexone EP Impurity H

Base Information

• Chemical Name: Naltrexone EP Impurity H
• CAS No.: 503090-99-1
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423
• Mol file: 503090-99-1.mol

Synonyms:

Chemical Property of Naltrexone EP Impurity H

Chemical Property:

• Boiling Point: 540.5±50.0 °C(Predicted)
• PKA: 9.17±0.40(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

99.0% Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naltrexone EP Impurity H

There total 2 articles about Naltrexone EP Impurity H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1-bromo-butane (109-65-9) + (+)-N-noroxymorphone (65700-72-3) → (4S,4aR,7aS,12bR)-3-butyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one (503090-99-1)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.1021/acs.jmedchem.5b00426

Reference yield:

C21H20N2O6 → (4S,4aR,7aS,12bR)-3-butyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one (503090-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 90 °C

With hydrogenchloride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.5b00426

upstream raw materials:

1-bromo-butane

(+)-N-noroxymorphone