1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one]

Base Information

• Chemical Name: 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one]
• CAS No.: 191977-79-4
• Molecular Formula: C₂₀H₂₀Cl₂N₄O₂
• Molecular Weight: 419.31
• Mol file: 191977-79-4.mol

Synonyms:

Chemical Property of 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one]

Chemical Property:

Purity/Quality:

99.0% Min ^*data from raw suppliers

3,3''-(Ethane-1,2-diyl)bis(1-(2-chloroethyl)-1H-benzo[d]imidazol-2(3H)-one) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3,3''-(Ethane-1,2-diyl)bis(1-(2-chloroethyl)-1H-benzo[d]imidazol-2(3H)-one) is an impurity of Filbanserin (F336750), an agonist of serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor. Binds dopamine receptors with Ki values ranging from 4-24 nM. Used to treat hypoactive sexual desire disorder in females.

Technology Process of 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one]

There total 2 articles about 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydro-2H-benzimidazol-2-one (615-16-7) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1-[3-(2-chloroethyl)-2-oxobenzimidazol-1-yl]-2-(2-oxobenzimidazol-1-yl)ethane + 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one] (191977-79-4) + 1,3-bis(2-chloroethyl)benzimidazolin-2-one (55470-74-1)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; Yield given. Multistep reaction. Yields of byproduct given; 1.) H₂O, room temp., 1 h, 2.) 50 deg C, 4 h, then 80 deg C, 2.5 h, and 100 deg C, 6 h;

DOI:10.1016/S0040-4020(97)00434-1

Reference yield:

1,3-dihydro-2H-benzimidazol-2-one (615-16-7) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 1,2-bis[3-(2-chloroethyl)benzimidazolin-2-one] (191977-79-4) + 1,3-bis[2-[3-(2-chloroethyl)-2-oxobenzimidazol-1-yl]ethyl]-2-oxobenzimidazole + C36H32N8O4 + 1,3-bis(2-chloroethyl)benzimidazolin-2-one (55470-74-1)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; Yield given. Multistep reaction. Yields of byproduct given; 1.) H₂O, room temp., 15 h, 2.) 100 deg C, 2 h;

DOI:10.1016/S0040-4020(97)00434-1

upstream raw materials:

1,3-dihydro-2H-benzimidazol-2-one

1,2-dichloro-ethane