2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one

Base Information

• Chemical Name: 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one
• CAS No.: 1313397-81-7
• Molecular Formula: C₂₄H₂₇N₅O₂S₂
• Molecular Weight: 481.643
• Mol file: 1313397-81-7.mol

Synonyms:

Chemical Property of 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one

There total 10 articles about 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-thiohydantoin (503-87-7) + 5-(2-(3-(4-methylpiperazin-1-yl)propyl)-1-oxoisoindolin-5-yl)thiophene-2-carbaldehyde (1313399-48-2) → 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one (1313397-81-7)

Guidance literature:

With acetic acid; 3-amino propanoic acid; for 15h; Reflux;

DOI:10.1021/jm401604x

Reference yield: 81.0%

→ 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one (1313397-81-7)

Guidance literature:

Reference yield:

5-(5-(dimethoxymethyl)thiophen-2-yl)-2-(3-hydroxypropyl)isoindolin-1-one (1313399-42-6) → 2-(3-(4-methylpiperazin-1-yl)propyl)-5-(5-((5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)thiophen-2-yl)isoindolin-1-one (1313397-81-7)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 3.5 h / 20 °C

2: sodium iodide / acetone / 1 h / 70 °C

3: tetrahydrofuran; N,N-dimethyl acetamide / 20 °C

4: toluene-4-sulfonic acid / acetone; water / 5 h / 50 °C

5: 3-amino propanoic acid; acetic acid / 15 h / Reflux

With toluene-4-sulfonic acid; acetic acid; triethylamine; sodium iodide; 3-amino propanoic acid; In tetrahydrofuran; N,N-dimethyl acetamide; water; acetone;

DOI:10.1021/jm401604x

upstream raw materials:

5-(5-(dimethoxymethyl)thiophen-2-yl)-2-(3-hydroxypropyl)isoindolin-1-one

3-(5-(5-(dimethoxymethyl)thiophen-2-yl)-1-oxoisoindolin-2-yl)propyl Methanesulfonate

5-(5-(dimethoxymethyl)thiophen-2-yl)-2-(3-iodopropyl)-isoindolin-1-one

2-thiohydantoin