2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile

Base Information

Chemical Name:2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile
CAS No.:347363-71-7
Molecular Formula:C₂₁H₁₆ClF₃N₂O₂S₂
Molecular Weight:484.95
Hs Code.:
Mol file:347363-71-7.mol

2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile

Chemical Property:

Boiling Point:593.7±50.0 °C(Predicted)
PKA:9.22±0.70(Predicted)
Density:1.48±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile

There total 4 articles about 2-(allylsulfanyl)-4-(2-chlorophenyl)-6-hydroxy-5-(2-thienylcarbonyl)-6-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 106-95-6
allyl bromide

: 4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione

: 347363-71-7
2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine

Guidance literature:: With potassium hydroxide; In ethanol; for 1h;
DOI:10.1023/A:1012739601781

Reference yield:

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 347363-71-7
2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / N-methylmorpholine / ethanol / 0.5 h / 20 °C

2: 77 percent / aq. KOH / ethanol / 1 h

With 4-methyl-morpholine; potassium hydroxide; In ethanol;
DOI:10.1023/A:1012739601781

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 347363-71-7
2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / N-methylmorpholine / ethanol / 0.5 h / 20 °C

2: 77 percent / aq. KOH / ethanol / 1 h

With 4-methyl-morpholine; potassium hydroxide; In ethanol;
DOI:10.1023/A:1012739601781