4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Base Information

Chemical Name:4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
CAS No.:1884640-99-6
Molecular Formula:C₁₈H₁₅N₃O₃S
Molecular Weight:353.401
Hs Code.:

Synonyms:

Suppliers and Price of 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NI42
1mg
$ 90.00

Cayman Chemical
NI-42
25mg
$ 313.00

Cayman Chemical
NI-42
10mg
$ 138.00

Cayman Chemical
NI-42
5mg
$ 75.00

Cayman Chemical
NI-42
1mg
$ 25.00

AK Scientific
4-Cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)benzenesulfonamide
25mg
$ 522.00

Total 5 raw suppliers

Chemical Property of 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

NI42 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description NI-42 is an inhibitor of the bromodomain and PHD finger-containing 1 (BRPF1) bromodomain (IC50 = 7.9 nM). It is selective for BRPF1 over BRPF2/BRD1, BRPF3, BRD9, and BRD4/BD1 (IC50s = 48, 260, 310, and 4,500 nM, respectively). NI-42 inhibits the growth of OCI-AML2, Nomo-1, THP-1, KG-1, and MV-4-11 acute myeloid leukemia (AML) cells (GI50s = 1.3, 4.6, 5.7, 7, and 9.9 μM, respectively) and a variety of non-AML cells (GI50s = 1-10 μM). It also inhibits the growth of DMS114 lung, HRA-19 colon, and RERF-LC-Sq1 lung cancer cells (GI50s = 16.6, 15.6, and 17.1 μM, respectively) but not NCI H1703 lung cancer cells (GI50 = >30 μM).
Uses NI-42 is a new chemical probe for the BRPFs (bromodomain and PHD finger-containing) suitable for cellular and invivo studies to explore the fundamental biology of these proteins.

Technology Process of 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

There total 7 articles about 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1425927-75-8
6-amino-1,3-dimethyl-6-quinolin-2-(1H)-one

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 1884640-99-6
4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b01583

Reference yield:

: 2721-59-7
3-methylcarbostyril

: 1884640-99-6
4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 5.5 h / 0 °C / Inert atmosphere

2: sulfuric acid; potassium nitrate / 4.5 h / 0 °C

3: 5%-palladium/activated carbon; hydrogen / ethanol / 7 h

4: pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; sulfuric acid; 5%-palladium/activated carbon; hydrogen; sodium hydride; potassium nitrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01583

Reference yield:

: 55539-83-8
1,3-dimethylquinolin-2-(1H)-one

: 1884640-99-6
4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; potassium nitrate / 4.5 h / 0 °C

2: 5%-palladium/activated carbon; hydrogen / ethanol / 7 h

3: pyridine / N,N-dimethyl-formamide / 20 °C

With pyridine; sulfuric acid; 5%-palladium/activated carbon; hydrogen; potassium nitrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01583