(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

Base Information

Chemical Name:(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid
CAS No.:1461641-21-3
Molecular Formula:CH₄O₃S*C₃₄H₃₃BrN₆O₃
Molecular Weight:749.685
Hs Code.:

(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

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Chemical Property of (E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

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Technology Process of (E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

There total 15 articles about (E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (E)-3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylic acid

: 75-75-2,98527-29-8
methanesulfonic acid

: 1461641-21-3
(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

Guidance literature:: In ethyl acetate; at 60 ℃; for 3.5h;

Reference yield:

: C₁₉H₁₇BrClN₃O

: 1461641-21-3
(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C

2: sodium hydroxide; water / methanol; tetrahydrofuran / 1 h / 65 - 68 °C

3: ethyl acetate / 3.5 h / 60 °C

With water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 1253789-90-0
isopropyl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate

: 1461641-21-3
(E)-3-[2-(1-{[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carbonyl]amino}cyclobutyl)-3-methyl-3H-benzimidazol-5-yl]acrylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / acetonitrile / 0.5 h / -6 °C

2.1: dichlorobis(tri(2-furyl)phosphine)palladium(II); trifuran-2-yl-phosphane; triethylamine / acetonitrile / 0.17 h / 23 °C / Inert atmosphere

2.2: 6 h / 81 - 83 °C / Inert atmosphere

3.1: potassium phosphate / acetonitrile; water / 2 h / 76 - 77 °C / Inert atmosphere

4.1: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one / 10 h / 50 - 53 °C / Inert atmosphere

5.1: 1-methyl-pyrrolidin-2-one; thionyl chloride / tetrahydrofuran / 1 h / 25 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 10 - 25 °C

7.1: sodium hydroxide; water / methanol; tetrahydrofuran / 1 h / 65 - 68 °C

8.1: ethyl acetate / 3.5 h / 60 °C

With 1-methyl-pyrrolidin-2-one; potassium phosphate; thionyl chloride; trifuran-2-yl-phosphane; dichlorobis(tri(2-furyl)phosphine)palladium(II); water; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; ethyl acetate; acetonitrile; 3.1: |Suzuki Coupling;