ML364

Base Information

Chemical Name:ML364
CAS No.:1991986-30-1
Molecular Formula:C₂₄H₁₈F₃N₃O₃S₂
Molecular Weight:517.552
Hs Code.:
Mol file:1991986-30-1.mol

Synonyms:

Suppliers and Price of ML364

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ML364
1mg
$ 65.00

DC Chemicals
ML364 >98%
1 g
$ 1800.00

DC Chemicals
ML364 >98%
100 mg
$ 550.00

ChemScene
ML364 99.94%
100mg
$ 880.00

ChemScene
ML364 99.94%
10mg
$ 120.00

ChemScene
ML364 99.94%
5mg
$ 75.00

ChemScene
ML364 99.94%
50mg
$ 520.00

Cayman Chemical
ML-364 ≥98%
25mg
$ 325.00

Cayman Chemical
ML-364 ≥98%
5mg
$ 78.00

Cayman Chemical
ML-364 ≥98%
1mg
$ 26.00

Total 13 raw suppliers

Chemical Property of ML364

Chemical Property:

PKA:6.51±0.50(Predicted)
Density:1.457±0.06 g/cm3(Predicted)
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

ML364 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses ML364 is a small molecular inhibitor of the deubiquitinase USP2, which accelerates cyclin D1 degrdation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma.

Technology Process of ML364

There total 2 articles about ML364 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 2010-06-2
2-Amino-4-phenylthiazole

: 2-((4-methylphenyl)sulfonamido)-4-(trifluoromethyl)benzoic acid

: 1991986-30-1
2-(4-methylbenzenesulfonamido)-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1074/jbc.M116.738567

Reference yield:

: 402-13-1
2-amino-4-trifluoromethylbenzoic acid

: 98-59-9
p-toluenesulfonyl chloride

: 1991986-30-1
2-(4-methylbenzenesulfonamido)-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / water / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; N,N-dimethyl-formamide;
DOI:10.1074/jbc.M116.738567