potassium 3-thiophenoyltrifluoroborate

Base Information

• Chemical Name: potassium 3-thiophenoyltrifluoroborate
• CAS No.: 1622923-64-1
• Molecular Formula: C₅H₃BF₃OS*K
• Molecular Weight: 218.049
• Mol file: 1622923-64-1.mol

Synonyms:

Chemical Property of potassium 3-thiophenoyltrifluoroborate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Potassium 3-thiophenoyltrifluoroborate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Acyltrifluroborates (KATs) are bench, air, and moisture stable reagents for rapid, chemoselective amide bond formations with hydroxylamines. These amide bond forming reactions proceed under aqueous conditions, without the need for coupling reagents or protecting groups. This product was introduced in collaboration with the Bode Research Group.

Technology Process of potassium 3-thiophenoyltrifluoroborate

There total 2 articles about potassium 3-thiophenoyltrifluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

C7H9BF3NS + potassium hydrogencarbonate (298-14-6) → potassium 3-thiophenoyltrifluoroborate (1622923-64-1)

Guidance literature:

In water; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.202014581

Reference yield: 56.0%

3-Bromothiophene (872-31-1) + potassium fluoride (7789-23-3) + (ethylthiotrifluoroborate)methane dimethyliminium zwitterion (1622923-36-7) → potassium 3-thiophenoyltrifluoroborate (1622923-64-1)

Guidance literature:

3-Bromothiophene; (ethylthiotrifluoroborate)methane dimethyliminium zwitterion; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With acetone; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

potassium fluoride; In tetrahydrofuran; hexane; water; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201403931

upstream raw materials:

3-Bromothiophene

potassium fluoride

(ethylthiotrifluoroborate)methane dimethyliminium zwitterion

potassium hydrogencarbonate