5-chloro-5,6,7,8-tetrahydroquinoline

Base Information

• Chemical Name: 5-chloro-5,6,7,8-tetrahydroquinoline
• CAS No.: 198401-82-0
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.638

Synonyms:

Chemical Property of 5-chloro-5,6,7,8-tetrahydroquinoline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-chloro-5,6,7,8-tetrahydroquinoline 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-5,6,7,8-tetrahydroquinoline

There total 3 articles about 5-chloro-5,6,7,8-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5,6,7,8-tetrahydroquinolin-5-ol (194151-99-0) → 5-chloro-5,6,7,8-tetrahydroquinoline (198401-82-0)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

5,6,7,8-tetrahydroquinolin-5-one (53400-41-2) → 5-chloro-5,6,7,8-tetrahydroquinoline (198401-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / NaBH₄ / methanol / 18 h / 0 - 20 °C

2: thionyl chloride / CH₂Cl₂ / 4 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm9800797

Reference yield:

3-amino-cyclohex-2-enone (5220-49-5) → 5-chloro-5,6,7,8-tetrahydroquinoline (198401-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) DMF, RT, 48 h, 2.) 140 deg C, 5 min

2: 91 percent / NaBH₄ / methanol / 18 h / 0 - 20 °C

3: thionyl chloride / CH₂Cl₂ / 4 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm9800797

upstream raw materials:

5,6,7,8-tetrahydroquinolin-5-ol

5,6,7,8-tetrahydroquinolin-5-one

3-amino-cyclohex-2-enone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 198401-82-0 5-chloro-5,6,7,8-tetrahydroquinoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send