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methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Base Information Edit
  • Chemical Name:methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • CAS No.:2093243-16-2
  • Molecular Formula:C17H13NO4
  • Molecular Weight:295.295
  • Hs Code.:
  • Mol file:2093243-16-2.mol
methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Synonyms:

Suppliers and Price of methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (Z)-Methyl3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • 50mg
  • $ 235.00
Total 5 raw suppliers
Chemical Property of methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate Edit
Chemical Property:
  • Melting Point:>215°C (dec.) 
Purity/Quality:

HPLC≥98% *data from raw suppliers

(Z)-Methyl3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Uses (Z)-Methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is a useful intermediate for the preparation of nintedanib esylate. Nintedanib is a drug for the treatment of idiopathic pulmonary fibrosis.
Technology Process of methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

There total 2 articles about methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester; With sodium methylate; In isopropyl alcohol; for 0.25h;
benzoyl chloride; In isopropyl alcohol; at -10 - -5 ℃; for 5h; Reagent/catalyst; Solvent;
DOI:10.1080/00397911.2017.1297459
Guidance literature:
Multi-step reaction with 2 steps
1: pyridine / 1.5 h / 0 - 80 °C
2: methanol; N,N-dimethyl-formamide / 12 h / 60 - 65 °C
With pyridine; In methanol; N,N-dimethyl-formamide;
Refernces Edit
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