7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Base Information

Chemical Name:7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline
CAS No.:4039-00-3
Molecular Formula:C₂₀H₂₈ClN₅
Molecular Weight:373.929
Hs Code.:

Synonyms:

Suppliers and Price of 7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4’-(7-Dechloroquinolinyl)Piperaquine
50mg
$ 165.00

Total 9 raw suppliers

Chemical Property of 7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Chemical Property:

Boiling Point:552.2±50.0 °C(Predicted)
Density:1.184±0.06 g/cm3(Predicted)

Purity/Quality:

> 95% ^*data from raw suppliers

4’-(7-Dechloroquinolinyl)Piperaquine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4’-(7-Dechloroquinolinyl) Piperaquine is an impurity of Piperaquine (P480050, tetraphosphate) which is a 4-aminoquinoline derivative used as an antimalarial agent. Piperaquine interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites.

Technology Process of 7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

There total 3 articles about 7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.61%

: 110-85-0
piperazine

: 4038-99-7
7-chloro-4-[4-(3-chloropropyl)piperazin-1-yl]quinoline

: 4039-00-3
7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Guidance literature:: With potassium carbonate; In isopropyl alcohol; for 2h; Reflux;

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 4039-00-3
7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / isopropyl alcohol / 36 h / Reflux

2: triethylamine / dichloromethane

3: potassium carbonate / isopropyl alcohol / 2 h / Reflux

With potassium carbonate; triethylamine; In dichloromethane; isopropyl alcohol;

Reference yield:

: 837-52-5
7-chloro-4-piperazinylquinoline

: 4039-00-3
7-chloro-4-(4-(3-(piperazin-1-yl)propyl)piperazin-1-yl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: potassium carbonate / isopropyl alcohol / 2 h / Reflux

With potassium carbonate; triethylamine; In dichloromethane; isopropyl alcohol;