(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate

Base Information

Chemical Name:(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate
CAS No.:112297-84-4
Molecular Formula:C₂₃H₃₈O₂Si
Molecular Weight:374.639
Hs Code.:
DSSTox Substance ID:DTXSID501106109

Synonyms:DTXSID501106109;(1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL (2S)-2-METHYL-3-PHENYL-2-(TRIMETHYLSILYL)PROPANOATE;112297-84-4;Benzenepropanoic acid, alpha-methyl-alpha-(trimethylsilyl)-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1R-[1alpha(S*),2beta,5alpha]]-

Suppliers and Price of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:374.264106985
Heavy Atom Count:26
Complexity:461

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CCC(C(C1)OC(=O)C(C)(CC2=CC=CC=C2)[Si](C)(C)C)C(C)C
Isomeric SMILES:C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)[C@](C)(CC2=CC=CC=C2)[Si](C)(C)C)C(C)C

Technology Process of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate

There total 6 articles about (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S)-2-methyl-3-phenyl-2-(trimethylsilyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29066-36-2,68539-56-0,86014-82-6,109716-85-0,127471-65-2,141552-99-0,141553-01-7,4951-48-8
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl propionate

: 112297-84-4
l-menthyl 2-methyl-2-(trimethylsilyl)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 30 min, 2.) from -78 deg C to RT, 1 h

2: 1.) LDA / 1.) THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
DOI:10.1021/jo00267a031

Reference yield:

: 112297-88-8
l-menthyl (trimethylsilyl)acetate

: 112297-84-4
l-menthyl 2-methyl-2-(trimethylsilyl)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) from -78 deg C to RT, overnight

2: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) from -78 deg C to RT

With lithium diisopropyl amide;
DOI:10.1021/jo00267a031

Reference yield:

: 2623-23-6
L-menthyl acetate

: 112297-84-4
l-menthyl 2-methyl-2-(trimethylsilyl)-3-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 30 min, 2.) from -78 deg C to RT, 1 h

2: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) from -78 deg C to RT, overnight

3: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) from -78 deg C to RT

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
DOI:10.1021/jo00267a031