C₁₀H₁₆O₂

Base Information

• Chemical Name: C₁₀H₁₆O₂
• CAS No.: 1426819-06-8
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.236
• Mol file: 1426819-06-8.mol

Synonyms:

Chemical Property of C₁₀H₁₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₆O₂

There total 2 articles about C₁₀H₁₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-2,2,4-trimethylcyclohex-3-en-1-one (153229-49-3) → C10H16O2 (1426819-06-8) + C10H16O2

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / Reflux

2: K₂OsO₂*2H₂O; potassium hexacyanoferrate(III); 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine / 1.5 h / 0 °C

With K₂OsO₂*2H₂O; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; potassium hexacyanoferrate(III); In tetrahydrofuran; 1: |Wittig Olefination / 2: |Sharpless Dihydroxylation;

DOI:10.1016/j.tetlet.2013.01.115

Reference yield:

C10H15I (1426819-09-1) → C10H16O2 (1426819-06-8) + C10H16O2

Guidance literature:

With K₂OsO₂*2H₂O; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; potassium hexacyanoferrate(III); at 0 ℃; for 1.5h; Overall yield = 96 %;

DOI:10.1016/j.tetlet.2013.01.115

upstream raw materials:

C₁₀H₁₅I

3-iodo-2,2,4-trimethylcyclohex-3-en-1-one