153229-49-3Relevant academic research and scientific papers
Synthesis of a diterpene taxoid skeleton, bicyclo[9.3.1]pentadecatriene
Shibuya, Satoshi,Isobe, Minoru
, p. 6677 - 6698 (2007/10/03)
The synthesis of bicyclo[9.3.1]pentadecatriene skeleton was investigated by employing cyclization reactions using two key precursors bearing acetylene cobalt complex. Cyclization for the synthesis of strained twelve-membered ring was achieved via Nicholas type reaction in reasonable yield. Reductive decomplexation of the dicobalt hexacarbonyl moiety of the cyclization product was achieved with n-Bu3SnH in the presence of a catalytic amount of NBS in 1,4-cyclohexadiene solvent.
Stereocontrolled syntheses of C-aryl taxanes by intramolecular Heck olefination. Novel instances of diastereofacial guidance by proximal coordination
Young, Wendy B.,Masters, John J.,Danishefsky, Samuel
, p. 5228 - 5234 (2007/10/02)
Stereospecific syntheses of baccatin III constructs bearing an aromatic C-ring (2a and 2b) have been demonstrated. A key step involves the use of an intramolecular Heck olefination reaction to form the C10-C11 bond. Novel stereospeci
A CONCISE SYNTHESIS OF A HIGHLY FUNCTIONALIZED C-ARYL TAXOL ANALOG BY AN INTRAMOLECULAR HECK OLEFINATION REACTION
Masters, John J.,Jung, David K.,Bornmann, William G.,Danishefsky, Samuel J.,Gala, Susan de
, p. 7253 - 7256 (2007/10/02)
A palladium(O) catalyzed intramolecular Heck olefination used to establish the C10-C11 connection in a highly functionalized taxane analog is described.
