phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate

Base Information

• Chemical Name: phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate
• CAS No.: 1233057-61-8
• Molecular Formula: C₃₉H₅₁NO₅Si₂
• Molecular Weight: 670.009
• Mol file: 1233057-61-8.mol

Synonyms:

Chemical Property of phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate

There total 1 articles about phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]-2-(quinolin-4-yl)butane (1233057-53-8) + (trimethylsilyl)ethynylmagnesium bromide (61210-52-4) + phenyl chloroformate (1885-14-9) → phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate (1233058-20-2) + phenyl 4-{4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]but-2-yl}-2-[(trimethylsilyl)ethynyl]-1,2-dihydroquinoline-1-carboxylate (1233057-61-8)

Guidance literature:

(R)-4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]-2-(quinolin-4-yl)butane; (trimethylsilyl)ethynylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 0.0166667h;

phenyl chloroformate; at -78 - -30 ℃; for 2.3h; optical yield given as %de; diastereoselective reaction;

DOI:10.1002/ejoc.200901478

upstream raw materials:

(R)-4-[(tert-butyldimethylsilyl)oxy]-1-[(4-methoxybenzyl)oxy]-2-(quinolin-4-yl)butane

(trimethylsilyl)ethynylmagnesium bromide

phenyl chloroformate