(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

Base Information

Chemical Name:(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate
CAS No.:1450609-07-0
Molecular Formula:C₃₁H₄₂N₂O₁₀S₂
Molecular Weight:666.814
Hs Code.:

(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

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Chemical Property of (3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

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Technology Process of (3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

There total 6 articles about (3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6881-49-8
tetrahydrothiopyran-3,5-dione

: 1450609-07-0
(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

: 1450609-08-1
(3aS,3bS,4S,7aR,8aR)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 2-chloro-1,3-dimethyl imidazolium chloride; sodium azide / acetonitrile / 0 °C / Inert atmosphere

2: Oxone / water; methanol / 3 h / Inert atmosphere

3: manganese triacetate; acetic acid / 24 h / 60 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr / Inert atmosphere

5: L-Selectride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

6: pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

7: triethylamine / acetonitrile / Inert atmosphere

With pyridine; Oxone; sodium azide; 2-chloro-1,3-dimethyl imidazolium chloride; palladium 10% on activated carbon; hydrogen; manganese triacetate; L-Selectride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400768f

Reference yield:

: 1450608-78-2
4-diazo-2H-thiopyran-3,5(4H,6H)-dione

: 1450609-07-0
(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

: 1450609-08-1
(3aS,3bS,4S,7aR,8aR)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: Oxone / water; methanol / 3 h / Inert atmosphere

2: manganese triacetate; acetic acid / 24 h / 60 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr / Inert atmosphere

4: L-Selectride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

5: pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: triethylamine / acetonitrile / Inert atmosphere

With pyridine; Oxone; palladium 10% on activated carbon; hydrogen; manganese triacetate; L-Selectride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400768f

Reference yield:

: 1450608-79-3
4-diazo-2H-thiopyran-3,5(4H,6H)-dione-1,1-dioxide

: 1450609-07-0
(3aS,3bR,4R,7aS,8aS)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

: 1450609-08-1
(3aS,3bS,4S,7aR,8aR)-6,6-dioxidooctahydro-2H-furo-[2,3-b]-thiopyrano[4,3-d]furan-4-yl ((2S,3R)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)-1-phenylbutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: manganese triacetate; acetic acid / 24 h / 60 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 760.05 Torr / Inert atmosphere

3: L-Selectride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4: pyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

5: triethylamine / acetonitrile / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; manganese triacetate; L-Selectride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm400768f