6-Methoxy-1-bromo naphthalene

Base Information

• Chemical Name: 6-Methoxy-1-bromo naphthalene
• CAS No.: 83710-62-7
• Molecular Formula: C11H9 Br O
• Molecular Weight: 237.096
• Hs Code.: 2909309090
• NSC Number: 148963
• DSSTox Substance ID: DTXSID60302133
• Nikkaji Number: J2.958.607A
• Wikidata: Q82046681
• Mol file: 83710-62-7.mol

Synonyms:6-Methoxy-1-bromo naphthalene;83710-62-7;1-bromo-6-methoxynaphthalene;1-bromo-6-methoxy-naphthalene;Naphthalene,1-bromo-6-methoxy-;5-Brom-2-methoxy-naphthalin;NSC 148963;(5-bromo-[2]naphthyl)-methyl ether;1,6-dibromo-2-methoxy-naphthalene;NSC148963;SCHEMBL5507954;DTXSID60302133;AC-858;AKOS015961094;AT25629;MB03398;NSC-148963;BS-48887;FT-0740002;2-Trifluoromethyl-6-chloro-5-pyridineboricacid

Chemical Property of 6-Methoxy-1-bromo naphthalene

Chemical Property:

• Vapor Pressure: 0.000459mmHg at 25°C
• Boiling Point: 324.7°C at 760 mmHg
• Flash Point: 134.7°C
• PSA: 9.23000
• Density: 1.447g/cm³
• LogP: 3.61090
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 235.98368
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

1-bromo-6-methoxy-naphthalene 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=CC=C2)Br

Technology Process of 6-Methoxy-1-bromo naphthalene

There total 16 articles about 6-Methoxy-1-bromo naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

((4-methoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (412041-55-5) → 1-bromo-6-methoxynaphthalene (83710-62-7)

Guidance literature:

With hydrogen bromide; platinum(II) chloride; In water; at 100 ℃; for 4h;

DOI:10.1021/jo0518295

Reference yield: 75.0%

4-bromo-7-methoxy-1,2-dihydronaphthalene (128557-02-8) → 1-bromo-6-methoxynaphthalene (83710-62-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; at 20 ℃; for 2h;

DOI:10.1002/anie.202005367

Reference yield: 74.0%

5-bromonaphthalen-2-ol (116632-05-4) + dimethyl sulfate (77-78-1) → 1-bromo-6-methoxynaphthalene (83710-62-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 24h;

DOI:10.1002/cmdc.201800158

upstream raw materials:

6-methoxynaphthylamine

((4-methoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane)

5-Nitro-2-naphthol

2-Methoxy-5-nitronaphthalene

Downstream raw materials:

5-Phenyl-[2]naphthol

methyl-(5-phenyl-[2]naphthyl)-ether

5-bromonaphthalen-2-ol

Refernces

• 1、 Egami, Hiromichi,Hamashima, Yoshitaka,Masuda, Kousuke,Niwa, Tomoki,Rouno, Taiki,Yamashita, Kenji. "Asymmetric Dearomative Fluorination of 2-Naphthols with a Dicarboxylate Phase-Transfer Catalyst". . p. 14101 - 14105. Retrieved 2020/06/10.
• 2、 -. "PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS". Page/Page column 102; 103. . Retrieved 2019/10/04.