[2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

Base Information

Chemical Name:[2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester
CAS No.:949528-61-4
Molecular Formula:C₂₇H₃₁ClN₄O₃S₂
Molecular Weight:559.153
Hs Code.:

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Chemical Property of [2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

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Technology Process of [2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

There total 5 articles about [2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 949527-59-7
4-chloro-6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidine

: 949528-61-4
[2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 12 h / 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

With di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 949527-58-6
6-(4-methoxyphenyl)-5-methyl-2-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-ol

: 949528-61-4
[2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Heating / reflux

2: boron tribromide / dichloromethane / 12 h / 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

With di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 949528-61-4
[2-({2-[4-(4-chloro-5-methyl-2-thiophen-2-yl-thieno[2,3-d]pyrimidin-6-yl)-phenoxy]-ethyl}-methyl-amino)-ethyl]-carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfur; diethylamine / ethanol / 36 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 12 h

3: trichlorophosphate / 3 h / Heating / reflux

4: boron tribromide / dichloromethane / 12 h / 20 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h

With hydrogenchloride; di-isopropyl azodicarboxylate; boron tribromide; sulfur; diethylamine; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;