(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

Base Information

Chemical Name:(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea
CAS No.:1445983-80-1
Molecular Formula:C₃₂H₄₃Cl₂N₅O₅S
Molecular Weight:680.696
Hs Code.:

(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

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Chemical Property of (R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

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Technology Process of (R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

There total 10 articles about (R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445985-47-6
tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate

: 1445983-80-1
(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide

3.1: hydrogenchloride / water; 1,4-dioxane / 1 h

4.1: acetonitrile / 0.5 h

4.2: 1.5 h / 80 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 1445983-80-1
(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: hydrogenchloride / water; 1,4-dioxane / 1 h

3.1: acetonitrile / 0.5 h

3.2: 1.5 h / 80 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 381229-74-9
4-methoxy-3,6-dichlorobenzaldehyde

: 1445983-80-1
(R)-1-(5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium chloride / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide

4.1: hydrogen; rhodium contaminated with carbon / ethyl acetate

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

6.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide

8.1: hydrogenchloride / water; 1,4-dioxane / 1 h

9.1: acetonitrile / 0.5 h

9.2: 1.5 h / 80 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; rhodium contaminated with carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308