1-phenyl-3-cyanoindole

Base Information

• Chemical Name: 1-phenyl-3-cyanoindole
• CAS No.: 473918-44-4
• Molecular Formula: C₁₅H₁₀N₂
• Molecular Weight: 218.258
• Mol file: 473918-44-4.mol

Synonyms:

Chemical Property of 1-phenyl-3-cyanoindole

Chemical Property:

Purity/Quality:

1-Phenyl-1H-indole-3-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-cyanoindole

There total 3 articles about 1-phenyl-3-cyanoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoaniline (615-36-1) → 1-phenyl-1H-indole-3-carbonitrile (473918-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride / water; dimethyl sulfoxide / 16 h / 130 °C / Inert atmosphere; Sealed tube

2: copper(l) iodide; potassium phosphate / toluene / 24 h / 110 °C / Schlenk technique; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; potassium phosphate; copper(l) iodide; In water; dimethyl sulfoxide; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

DOI:10.1039/d0cc05439a

Reference yield:

2-iodophenylamine (615-43-0) → 1-phenyl-1H-indole-3-carbonitrile (473918-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride / water; dimethyl sulfoxide / 16 h / 130 °C / Inert atmosphere; Sealed tube

2: copper(l) iodide; potassium phosphate / toluene / 24 h / 110 °C / Schlenk technique; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; potassium phosphate; copper(l) iodide; In water; dimethyl sulfoxide; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

DOI:10.1039/d0cc05439a

Reference yield:

o-chloroaniline (95-51-2) → 1-phenyl-1H-indole-3-carbonitrile (473918-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride / water; dimethyl sulfoxide / 16 h / 130 °C / Inert atmosphere; Sealed tube

2: copper(l) iodide; potassium phosphate / toluene / 24 h / 110 °C / Schlenk technique; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; potassium phosphate; copper(l) iodide; In water; dimethyl sulfoxide; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling;

DOI:10.1039/d0cc05439a

upstream raw materials:

o-chloroaniline

2-bromoaniline

2-iodophenylamine

Refernces