Technology Process of 4-Thiazolidinecarboxylic acid,
3-[3-[[(4-methoxyphenyl)methyl]thio]-2,2-dimethylpropyl]-2-thioxo-,
methyl ester, (R)-
There total 8 articles about 4-Thiazolidinecarboxylic acid,
3-[3-[[(4-methoxyphenyl)methyl]thio]-2,2-dimethylpropyl]-2-thioxo-,
methyl ester, (R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2N aq. NaOH / ethanol / Ambient temperature
2: LiAlH4 / tetrahydrofuran; diethyl ether / Ambient temperature
3: (COCl)2, dimethyl sulfoxide / CH2Cl2 / 0.17 h / -60 °C
4: 1.) molecular sieves 3A, 2.) NaBH3CN / 1.) methanol, RT, 30 min, 2.) methanol, RT, overnight
5: (n-Bu)3P / methanol; H2O / 2 h / Ambient temperature
6: CHCl3 / 1 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tributylphosphine; 3 A molecular sieve; sodium cyanoborohydride; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water;
DOI:10.1248/cpb.41.876
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2N aq. NaOH / ethanol / Ambient temperature
2: LiAlH4 / tetrahydrofuran; diethyl ether / Ambient temperature
3: (COCl)2, dimethyl sulfoxide / CH2Cl2 / 0.17 h / -60 °C
4: 1.) molecular sieves 3A, 2.) NaBH3CN / 1.) methanol, RT, 30 min, 2.) methanol, RT, overnight
5: (n-Bu)3P / methanol; H2O / 2 h / Ambient temperature
6: CHCl3 / 1 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; tributylphosphine; 3 A molecular sieve; sodium cyanoborohydride; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water;
DOI:10.1248/cpb.41.876
- Guidance literature:
-
Multi-step reaction with 4 steps
1: (COCl)2, dimethyl sulfoxide / CH2Cl2 / 0.17 h / -60 °C
2: 1.) molecular sieves 3A, 2.) NaBH3CN / 1.) methanol, RT, 30 min, 2.) methanol, RT, overnight
3: (n-Bu)3P / methanol; H2O / 2 h / Ambient temperature
4: CHCl3 / 1 h / Ambient temperature
With
oxalyl dichloride; tributylphosphine; 3 A molecular sieve; sodium cyanoborohydride; dimethyl sulfoxide;
In
methanol; dichloromethane; chloroform; water;
DOI:10.1248/cpb.41.876
