N₉-benzylpyrido[3,4-b]indol-1(2H)-one

Base Information

• Chemical Name: N₉-benzylpyrido[3,4-b]indol-1(2H)-one
• CAS No.: 28303-87-9
• Molecular Formula: C₁₈H₁₄N₂O
• Molecular Weight: 274.322
• Mol file: 28303-87-9.mol

Synonyms:

Chemical Property of N₉-benzylpyrido[3,4-b]indol-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₉-benzylpyrido[3,4-b]indol-1(2H)-one

There total 4 articles about N₉-benzylpyrido[3,4-b]indol-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2E)-3-(1-benzyl-1H-indol-3-yl)prop-2-enoate (92637-35-9) → N9-benzylpyrido[3,4-b]indol-1(2H)-one (28303-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 5 h / 20 °C

2: diphenylphosphoranyl azide; triethylamine / 1,2-dichloro-benzene / 0.25 h / 60 °C / Inert atmosphere

3: 1,2-dichloro-benzene / 1 h / 180 °C / Microwave irradiation; Inert atmosphere

With diphenylphosphoranyl azide; triethylamine; sodium hydroxide; In methanol; water; 1,2-dichloro-benzene; 2: |Curtius Rearrangement;

DOI:10.3987/COM-16-S(S)13

Reference yield:

1-Benzylindole-3-carboxaldehyde (10511-51-0) → N9-benzylpyrido[3,4-b]indol-1(2H)-one (28303-87-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

2: sodium hydroxide / methanol; water / 5 h / 20 °C

3: diphenylphosphoranyl azide; triethylamine / 1,2-dichloro-benzene / 0.25 h / 60 °C / Inert atmosphere

4: 1,2-dichloro-benzene / 1 h / 180 °C / Microwave irradiation; Inert atmosphere

With diphenylphosphoranyl azide; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; 1,2-dichloro-benzene; 1: |Wittig Olefination / 3: |Curtius Rearrangement;

DOI:10.3987/COM-16-S(S)13

Reference yield:

(E)-3-(1-benzyl-1H-indol-3-yl)acrylic acid → N9-benzylpyrido[3,4-b]indol-1(2H)-one (28303-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylphosphoranyl azide; triethylamine / 1,2-dichloro-benzene / 0.25 h / 60 °C / Inert atmosphere

2: 1,2-dichloro-benzene / 1 h / 180 °C / Microwave irradiation; Inert atmosphere

With diphenylphosphoranyl azide; triethylamine; In 1,2-dichloro-benzene; 1: |Curtius Rearrangement;

DOI:10.3987/COM-16-S(S)13

upstream raw materials:

ethyl (2E)-3-(1-benzyl-1H-indol-3-yl)prop-2-enoate

1-Benzylindole-3-carboxaldehyde