92637-35-9Relevant academic research and scientific papers
Mechanochemically Activated Oxidative Coupling of Indoles with Acrylates through C-H Activation: Synthesis of 3-Vinylindoles and β,β-Diindolyl Propionates and Study of the Mechanism
Jia, Kan-Yan,Yu, Jing-Bo,Jiang, Zhi-Jiang,Su, Wei-Ke
, p. 6049 - 6055 (2016)
Construction of 3-vinylindoles (3) and β,β-diindolyl propionates (4) through solvent-free C-H functionalization has been explored under high-speed ball-milling conditions. The reaction selectivity is influenced by the catalyst dramatically: Pd(OAc)2
One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via curtius rearrangement & microwave-assisted thermal electrocyclization
Nishiyama, Takashi,Hatae, Noriyuki,Hayashi, Kaori,Obata, Manami,Taninaka, Kimiko,Yamane, Masahiro,Oda, Shota,Abe, Takumi,Ishikura, Minoru,Hibino, Satoshi,Choshi, Tominari
, p. 251 - 267 (2017/07/28)
We investigated the one-pot synthesis of several fused 2-pyridone ring systems based on a Curtius rearrangement, followed by a microwave-assisted thermal electrocyclization of a 2-aza-6?-electron system including isocyanate. We synthesized seven heterocyclic compounds containing a fused 2-pyridone ring. In these results, the one-pot synthesis of fused 2-pyridone ring system 5 from (E)-acrylic acids 1 under microwave irradiation conditions was more effective than the conventional reaction conditions in terms of the yield and the reaction time.
Non-redox metal ion promoted oxidative coupling of indoles with olefins by the palladium(II) acetate catalyst through dioxygen activation: Experimental results with DFT calculations
Zhang, Sicheng,Chen, Zhuqi,Qin, Shuhao,Lou, Chenlin,Senan, Ahmed M.,Liao, Rong-Zhen,Yin, Guochuan
supporting information, p. 4146 - 4157 (2016/06/14)
Developing new catalytic technologies through C-H bond activation to synthesize versatile pharmaceuticals has attracted much attention in recent decades. This work introduces a new strategy in catalyst design for Pd(ii)-catalyzed C-H bond activation in wh
CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF
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Page/Page column 81; 153, (2013/09/12)
The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
DIRECT REGIOSELECTIVE VINYLATION OF INDOLES USING PALLADIUM (II) CHLORIDE
Murakami, Yasuoki,Yokoyama, Yuusaku,Aoki, Tsuyoshi
, p. 1493 - 1496 (2007/10/02)
Direct regioselective vinylation at C3-position of ethyl indole-2-carboxylate, its N-benzyl derivative, and N-benzylindole with various conjugated olefins was accomplished in the presence of palladium (II) chloride and acetate salt in good to moderate yie
